In order to determine the exact dosing of botulinum toxin A, Chen et al. (2021) investigated the influence of different doses on surgical scars in a randomized study with 24 participants of different genders in middle age. For this purpose, the drug was injected intradermally into scars after tumour excisions without muscle involvement.
Here, different doses were injected into each half of the surgical wound closure following surgery. On the one hand a lower dose with 4 Botox units per injection point at a distance of one centimeter and on the other hand a higher dose with 8 Botox units per injection point.